Ismith Khan was born in Trinidad in 1925. He grew up within a Muslim family, who came from the country to Port of Spain, strongly influenced by his grandfather, a Pathan from Northern India, who was a militant community leader who had been shot and wounded by the colonial authorities in their suppression of the San Fernando Hosay rebellion of 1884. Ismith Khan makes use of this background in his first novel, The Jumbie Bird, 1961.
Ismith Khan attended Queen's Royal College in Port of Spain and later worked as a reporter on the Trinidad Guardian. He was a close Trinidad friend of Sam Selvon, who edited the literary page of this paper before he emigrated to the UK. Khan himself left Trinidad in the 1950s to study at Michigan State University and Johns Hopkins University.